Changes in global gene expression profiles induced by HPV 16 E6 oncoprotein variants in cervical carcinoma C33-A cells
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چکیده
منابع مشابه
Effect of β-sitosterol on the expression of HPV E6 and p53 in cervical carcinoma cells
AIM OF THE STUDY In the absence of effective therapeutic strategies, cervical carcinoma continues to be second on the list of mortality rates of malignant tumours found in women. We investigated the effects of β -sitosterol, a natural product isolated from traditional Chinese herbs, on Caski and HeLa cervical carcinoma cells. MATERIAL AND METHODS Morphological changes were examined by light m...
متن کاملTargeting of HPV-16+ Epithelial Cancer Cells by TCR Gene Engineered T Cells Directed against E6.
PURPOSE The E6 and E7 oncoproteins of HPV-associated epithelial cancers are in principle ideal immunotherapeutic targets, but evidence that T cells specific for these antigens can recognize and kill HPV(+) tumor cells is limited. We sought to determine whether TCR gene engineered T cells directed against an HPV oncoprotein can successfully target HPV(+) tumor cells. EXPERIMENTAL DESIGN T-cell...
متن کاملHuman papillomavirus 16 E6 variants are more prevalent in invasive cervical carcinoma than the prototype.
High-risk human papillomavirus (HPV) is a known risk factor in the etiology of cervical intraepithelial neoplasia (CIN) I-III and invasive cervical carcinoma (ICC). The most severe preinvasive lesion is CIN III, and it is still not entirely understood why some cases progress to invasion, whereas others do not. Our hypothesis that this could be predicted by intratype variation of the immortalizi...
متن کاملHuman Papillomavirus (HPV) 16 E6 Variants in Tonsillar Cancer in Comparison to Those in Cervical Cancer in Stockholm, Sweden
BACKGROUND Human papillomavirus (HPV), especially HPV16, is associated with the development of both cervical and tonsillar cancer and intratype variants in the amino acid sequence of the HPV16 E6 oncoprotein have been demonstrated to be associated with viral persistence and cancer lesions. For this reason the presence of HPV16 E6 variants in tonsillar squamous cell carcinoma (TSCC) in cervical ...
متن کاملFOXM1 induced by E6 oncoprotein promotes tumor invasion and chemoresistance in HPV-infected lung cancer
Induction of FOXM1 expression by E6 oncoprotein via the MZF1/NKX2-1 axis is responsible for soft-agar growth, invasiveness, and stemness in HPV-positive oral and lung cancer cells. Among patients, the presence of HPV16/18 DNA was positively correlated with NKX2-1 and FOXM1 expression in oral and lung tumors. When oral or lung cancer patients were individually divided into four subgroups by two ...
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ژورنال
عنوان ژورنال: Virology
سال: 2016
ISSN: 0042-6822
DOI: 10.1016/j.virol.2015.11.017